Issue: 2019, Vol. 24, No. 1

I. N. Fetisova, A. I. Malyshkina, N. S. Fetisov

GENETIC POLYMORPHISM OF FOLATE CYCLE IN WOMEN WITH INCOMPLETE PREGNANCY

Keywords

incomplete pregnancy, folates, genes, allele.

Abstarct

Folate status disorder in women negatively influenced reproductive function realization. Objective - to study genetic polymorphism of folate cycle in women with habitual incomplete pregnancy (HIP) and sporadic misbirth at early terms. Material and methods. 174 women were examined. 122 patients with incomplete pregnancy at early terms were enrolled into basic group, among them 83 ones had HIP (the first subgroup); 39 ones had one spontaneous misbirth before the 12th week (the second subgroup). 52 women with normal childbearing were enrolled into control group. Genetic polymorphisms MTHFRC677T (rslSO1133), MTHFRA1298C (rslSO1131), MTRRA66G (rs1801394) were studied by polymerase chain reaction technique in real time regime. Results and discussion. Frequency of heterozygote bearing of negative allele MTHFR677T in women of both subgroups was similar and trustworthy increased the analogous index in control group: in 50,6% patients with HIP, in 56,41% ones with SM, in 32,7% ones with normal childbearing fp = 0,04). Frequency of homozygote genotype MTHFR677T among women with HIP and SM was similar (9,63 and 10,25% respectively) and exceeded this index in the control group (1,9%, p > 0,05). The analysis of gene and genotype frequencies by polymorphisms MTHFRA1298C and MTRRA66G did not reveal trustworthy distinctions between women from basic and control groups. Conclusions. The presence of MTHFR677T allele in woman genotype was proved to be risk factor for SM in first trimester and for HIP at early terms.

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• Фетисова И.Н. 33-36