Issue: 2018, Vol. 23, No. 1

Majidova E. N., Saidkhojaeva S. N., Karimov Kh. Ya., Boboev K. T.

CYTOGENETIC ALTERATIONS IN THE KARYOTYPE IN CHILDREN WITH ATTENTION-DEFICIT HYPERACTIVITY DISORDER

Keywords

attention-deficit hyperactivity disorder, karyotype, Y chromosome, phenotype, anti-social behaviour, children

Abstarct

Objective is to analyze the association of attention-deficit hyperactivity disorder (ADHD) and Y chromosome size variability and other possible cytogenetically detectable karyotype alterations. Material and methods. 62 children aged 6-15 years with clinically diagnosed ADHD were examined. 45 conditionally healthy children without clinically determined signs of ADHD composed the control group.Results and conclusions. The increase of Y chromosome length owing to its q-shoulder increase was detected in children with ADHD. In these children cytogenetically detected alterations were revealed more often than in children without the disorder clinical signs. This fact was proved to be one of the factors to prognosticate the possibility of this disorder formation and was allowed to be used in screening and prenatal diagnosis for early detection of predisposition to ADHD development.

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