Issue: 2018, Vol. 23, No. 1

Maslyakov V. V., Barsukov V. G., Uskov A. V.

THE ALTERATIONS OF ADHESIVE PROPERTIES OF ENDOTHELIUM VASCULAR WALL IN VARIOUS NECK WOUNDS

Keywords

neck wounds, adhesive properties of endothelium vascular wall, nearest postoperative period

Abstarct

Objective is to study the changes of adhesive properties of endothelium vascular wall in various neck wounds in the nearest postoperative period. Material and methods. the alterations of adhesive properties of endothelium vascular wall were analyzed (sICAM-1; sV- CAM-1; sPECAM-1; sP- and sE-selectines) and the concentration of anti-inflammatory cytokines (IL-1β and FNO-alpha) in 30 patients with neck wounds (15 - with bullet wounds and 15 - with stab-incised wounds) on the 1, 3, 5, 7, 10 and 18th day in postoperative period. Results. In the group with bullet neck wounds the increase of anti-inflammatory cytokines level and soluble forms of endothelium adhesive molecules was registered beginning from the first postoperative days; and in the group with stab-incised neck wounds the examined parameters practically did not differ from the findings in relatively healthy persons. The growth of all examined indices in both groups was registered to the 3rd day in postoperative period. The indices were significantly higher in patients with bullet wounds than in patients with stab-incised wounds. On the 10th day after the operation the complete normalization of parameter was revealed in the group with stab-incised wounds but only partial normalization was marked in the group with bullet wounds.Conclusions. The alterations of soluble forms of endothelium adhesive molecules in serum in neck wounds depended on the wound character. In bullet wounds the level growth of soluble forms of endothelium adhesive molecules in serum was mostly expressed beginning from the 1st day after the operation and the restoration was observed later than in stab-incised wounds - on the 18th day after the operation.

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