Issue: 2023, Vol. 28, No. 3
PATIENTS WITH CHRONIC HEPATITIS B: SAFETY AND EFFECTIVENESS OF ANTIVIRAL TREATMENT IN AMBULATORY SETTINGS
- Keywords
- chronic hepatitis B, ambulatory supervision, antiviaral treatment
- Abstarct
- Patients with chronic hepatitis В (CHВ) need dispensary supervision by infectious diseases specialist in order to solve the problem of the need for timely initiation of antiviral therapy (AVT), which allows to prevent liver cirrhosis (LC) formation and hepatocellular carcinoma (HCC) development. Objective – to estimate the efficacy and safety of antiviral therapy in patients with CHB in ambulatory settings. Material and methods. The authors analyze the data of 26 patients with verified diagnosis of CHB who have undergone and are currently undergoing AVT. AVT efficacy and safety are evaluated on the basis of clinical data; viral load (VL) level, biochemical parameters. Glomelurar filtration rate (GFR) is determined by Cockcroft-Gault formula (in ml/min) in order to assess renal safety. Results and discussion. Retrospective assessment of AVT clinical effectiveness by pegylated interferons (IFN) within 48 weeks in 7 patients with CHB and in 19 patients using nucleos(t)ide analogues (NA) was performed. AVT usage was characterized by the improvement of clinical status in patients, normalization of blood transaminase level, sharp decrease of VL level in patients treated with NA – to an undetectable level. Serum creatinine (SC) level indicators in IFN and NA treatment remained within reference values throughout the entire treatment period. Conclusion. Modern antiviral preparations of direct action (APDA) were proved to be effective and safe and it allowed to carry out this therapy on an out-patient basis.
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