Issue: 2023, Vol. 28, No. 3

А. А. Ageev, I. А. Panova, G. N. Kuzmenko, I. G. Popova, М. М. Klycheva

PLATELET GROWTH FACTOR AND THROMBOSPONDIN CONTENT IN PLATELET LYSATES IN PREGNANT WOMEN WITH HYPERTENSIVE DISORDERS

Keywords

hypertensive disorders, preeclampsia, thrombocytes, platelet growth factor, thrombo­ spondin

Abstarct

Objective – to study platelet growth factor and thrombospondin content in platelet lysates in pregnant women with hypertensive disorders of various origins. Material and methods. 166 pregnant women were examined; the basic group consisted of 119 patients with hypertensive disorders: 44 with preeclampsia (PE), appeared de novo, 37 – with PE against the background of chronic arterial hypertension (CAH) and 38 – with CAH. 47 normotensive women composed the control group. Levels of platelet growth factor (PDGF-BB) and thrombospondin (TSP-1) were evaluated by enzyme immunoassay (EIA) with spectrophotometer ELx808IU, Biotek (USA). Results and discussion. PDGF level was significantly lower in women of all examined groups in comparison with the control one. TSP content was significantly higher in the groups with PE (both appeared de novo and against the background of CAH) in comparison with both control group and CAH group. Platelet growth factor level PDGF was trustworthy lower in women of all examined groups (in CAH – 584,5 [410,3; 708,8] pg/ml, in women with PE – 561,8 [330,2; 721,1] pg/ml) in comparison with control group (1099,0 [978,9; 1293,8] pg/ml, р< 0,05). Thrombospondin content TSP was significantly higher in the groups with PE (568,4 [517,6; 598,0] ng/ml) in comparison with both control group (529,1 [498,0; 560,5] ng/ml), and the group with CAH (527,7 [496,3; 562,0] ng/ml). Conclusion. Such revealed considerable changes of PDGF and TSP levels in pregnant women with hypertensive disorders testified to platelet dysfunction in these complications of pregnancy.

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