Issue: 2021, Vol. 26, No. 4
MICROBIOLOGICAL EXAMINATION OF SPUTUM MICROFLORA IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA WHICH WAS CAUSED BY SARS-CoV-2 VIRUS
- Keywords
- community-acquired pneumonia, SARS-CoV2, Covid-19, antibiotic resistance, antibacterial sensitivity, bacterial strains
- Abstarct
- Objective – to study the microflora spectrum of low respiratory passages and to estimate antibiotic resistance of microorganisms in community-acquired pneumonia which is associated with SARS-CoV-2. Material and methods. Nonspecific microflora of respiratory secret of low respiratory passages was examined in patients with community-acquired pneumonia which was caused by identified virus SARS-CoV-2. Patients were treated in COVID hospitals in the city of Voronezh within the period from November 2020 to April 2021. The identification of microorganisms in the sputum was performed by mass spectrometry with bacteriological analyzer; antibiotic sensitivity was determined by hardware and discodiffuse methods. Results and discussion. It was defined that gram-negative bacteria dominated in sputum microflora spectrum with prevalence of representatives of bacterial family Enterobacterales (K. pneumoniae) and non-fermenting gramnegative bacteria (Acinetobacterspp.). High resistance level of bacterial family Enterobacterales to cephalosporins of the III generation and to penicillins was revealed, Kebsiellapneumoniae also demonstrated tolerance to cephalosporins of the III generation. Representatives of Acinetobacter showed tolerance to cephalosporins of the I–IY generations. Gram-positive bacteria were characterized by tolerance to fluoroquinolones of the II-III generations, carbapenems, penicillin group, cephalosporins of the III generation. In the spectrum of microorganisms which were revealed from the sputum in patients with pneumonia which was caused by Covid-19, Candidaalbicans and C. Glabrata yeast-like fungus were identified in 50% cases, and they were sensitive to voriconazole and to fluconazole
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