Issue: 2020, Vol. 25, No. 3-4

I. N. Fetisova, А. I. Мalyshkina, I. А. Panova, Е. L. Boiko, S. S. Semenenko, N. S. Fetisov, S. Yu. Ratnikova

PREGRAVIDITY PREPAREDNESS FROM THE POINT OF GENETICIST VIEW

Keywords: hereditary and congenital pathology prevention, mutation, polymorphism, genes of folate cycle.
Abstarct: Folate metabolism disorder combined with folate alimentary insufficiency and negative alleles presence in genotype in folate cycle genes is one of risk factors for hereditary and congenital pathology in posterity. Folate cycle is rather complicated cascade process in the course of which metyl groups transfer takes place and homocysteine metabolism is realized and its excess is transferred into methionine. Folate metabolism disorder due to DNA methylation profile alteration in cells determines the inclinations in the activation of genes and all cellular processes which underlies embryogenesis (proliferation, differentiation, migration and selective grading, apoptosis). Folate cycle disorder is a risk factor for hyperhomocysteinemia. Homocysteine level heightening is conducive to epithelial dysfunction progressing, vascular atherosis, desynchronization of fibrinolysis and fibrinoformation processes, vasoconstriction and fetus ovum nidation disorder, trophoblast and placentation invasion, and it stipulates obstetrics pathology development. Due to high incidence of low functional polymorphism in methylentetrahydrofolate-reductase (MTHFR 677T) in national populations it is recommended to administer vitamin-mineral complexes with active form of folate acid in pregravidity preraredness (PP).

BULLETIN
of the Ivanovo Medical Academy^{ISSN 1606-8157}