Issue: 2019, Vol. 24, No. 3

N. Brodovskaya, G. A. Batrak

INFLUENCE OF ANTIHYPERGLYCEMIC THERAPY ON GLYCEMIA VARIABILITY IN PATIENTS WITH 2 TYPE DIABETES MELLITUS WHICH WAS REVEALED FOR THE FIRST TIME

Keywords

glycemia variability, 2 type diabetes mellitus, medicamental therapy.

Abstarct

Actuality – the influence of antihyperglycemic preparations on glycemia variability parameters had some differences according to the obtained findings. The selection of antihyperglycemic preparation was of great importance for the moment of diagnosis of 2 type diabetes mellitus. Objective – to estimate the influence of different classes of antihyperglycemic preparations on glycemia variability in patients with 2 type diabetes mellitus which was revealed for the first time. Material and methods. 37 patients with 2 type diabetes mellitus which was revealed for the first time who did not reach glycemic purposeful meanings in diet therapy or monotherapy with metmorphin were enrolled in the study. All patients were divided into two groups in dependence on therapy intensification scheme: the 1st group – 19 patients who were administered sulphonylurea preparations and the 2nd one – 18 patients who were administered dipeptidyl-peptidase 4 inhibitors. In 28 days of the treatment the comparison of standard parameters of glycemic control (glycemia level on an empty stomach and average daily glycemia level) and glycemia variability (standard deviation SD, coefficient of variation CV) were performed; frequency and severity of hypoglycemic states were evaluated. Results and discussion. In four weeks of the treatment similar trustworthy decrease of glycemia level on an empty stomach and average glucose content were marked in both groups. At the same time standard deviation index (1,9 + 1,1 and 2,5 + 1,7 mmol/l respectively) and coefficient of variation index (28 + 5,3 and 35 + 8,1%, p < 0,05) were statistically significantly lower in the 2nd group. The number of patients with standard deviation higher than 2 mmol/l (with high glycemia variabili-ty) in the first group was amounting to 72%, in the 2nd group – 46% (p < 0,05). Hypoglycemic states were frequently marked in the 1st group.Conclusion. The data upon the advantages of antihyperglycemic preparations upon the influence on glycemia variability allowed to improve the selection of medicamental therapy in patients with 2 type diabetes mellitus which was revealed for the first time.

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