Issue: 2013, Vol. 18, No. 3
Nonlipid effects of micronizing phenofibrate in patients with 2 type diabetes and atherogenic dyslipidemia
- Keywords
- diabetes mellitus, dyslipidemia, endothelium function, C-reactive protein, phenofibrate
- Abstarct
- 63 patients with 2 type diabetes and dyslipidemia were observed in order to study nonlipid effects of micronizing phenofibrate in the dose of 145 mg. The basic values dynamics was analyzed before and after 6 months of the administered treatment. The micronizing phenofibrate in complex therapy in patients with 2 type diabetes decreased C-reactive protein level for certain and improved endothelium function. The obtained indices of humeral artery diameter growth correlated with C-reactive protein level and to small extent depended on lipid and carbohydrate metabolism monitoring. It allowed to suppose that phenophibrate had nonlipid (pleiotropic) effects.
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