Issue: 2013, Vol. 18, No. 3
The role of natural killers in the pathogenersis of hysteromyoma rapid growth
- Keywords
- hysteromyoma, natural killers, transforming growth factor-beta, interferon gamma, vascular endothelial factor
- Abstarct
- The aim of the study was the examination of the content of natural killers and TGFbeta1 and IFNy cytokines produced by them, VEGF expression on the local level in women with hysteromyoma with different temp and type of its growth. It was determined that there was the increase of IFNy production by natural killers and by lymphocytes in endometrium in women with stable small hysteromyoma. The increase of natural killers’ content, production of TGFbeta1 by natural killers and by lymphocytes in endometrium was demonstrated in women with hysteromyoma rapid growth and “true” tumor growth. In myoma nodes’ tissue with “true” type of its growth TGFbeta1 production was increased in comparison with intact endometrium and myoma nodes’ tissue with false type of its growth. Heightened VEGFA expression was revealed in the endothelium of capillaries and intramural arteries of myoma nodes in “true” type of the tumor growth.
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