Issue: 2012, Vol. 17, No. 2

Lipin Михаил Александрович, Malyshkina Анна Ивановна, Fetisova Ирина Николаевна, Diuzhev Жан Александрович, Ratnikova Светлана Юрьевна

THE SIGNIFICANCE OF THE GENES OF THE MAIN COMPLEX OF HISTOCOMPATIBILITY IN THE PROGRAM OF EXTRACORPOREAL FERTILIZATION

Keywords

histocompatibility complex, HLA, genes, alleles, sterility, oocyte, extracorporeal fertilization

Abstarct

126 women who were directed to the procedure of extracorporeal fertilization due to tuboperitoneal sterility were examined. The analysis of polymorphism of genes of HLA system, II class revealed the association between the presence of DQA1* alleles in genotype and decreased follicular reserve; DQB1*0301/4 alleles and positive reaction of ovaries to superovulation induction.