INHERITANCE OF BALANCED STRUCTURAL REARRANGEMENT OF CHROMOSOMES IN THREE GENERATIONS OF THE FAMILY

Keywords: chromosomes, chromosomal aberrations, translocation, reproductive dysfunction
Abstarct: The transmission of a balanced translocation involving chromosomes 4 and 22 pairs in three generations of the family was followed up. Carriers of structural chromosomal rearrangement have an increased risk of reproductive dysfunction due to the deviation of gametogenesis and the formation of an aneuploid embryo/fetus. Prenatal karyotyping or preimplantation genetic testing for aneuploidy (PGT-A) in the in vitro fertilization (IVF) program is recommended in order to avoid the birth of a child with a chromosomal abnormality

BULLETIN
of the Ivanovo Medical Academy^{ISSN 1606-8157}