PREDICTION OF PREMATURE BIRTH IN WOMEN WITH ISTHMIC CERVICAL INSUFFICIENCY AND TRANSVAGINAL CERCLAGE

Keywords: premature birth, isthmic cervical insufficiency, transvaginal cerclage, protein binding free fatty acids 4
Abstarct: Objective – to determine FABP4 concentration in the blood serum and its significance for premature birth (PB) prediction in pregnant women with isthmic cervical insufficiency (ICI). Material and methods. 48 patients in the second trimester of gestation were enrolled in the study. 25 women with ICI with indications for the applying of transvaginal suture composed the main group, 23 patients with physiological course of pregnancy formed the control group. FABP4 concentration in the blood serum was determined by the method of enzyme immunoassay. Results and discussion. FABP4 concentration in the blood serum in women of the main group (18,57 [8,7; 22,47] ng/ml) was higher than in the control group (13,84 [9,66; 15,97] ng/ml, р = ,017). In 13 of 25 women of the main group FABP4 was amounting to more than 25,57 and less than 8,7 ng/ml, 11 of them had premature births, and 2 had full-term birth. In 12 patients FABP4 was in the range of 8,7–25,57 ng/ml, in all women, pregnancy ended with timely delivery. Conclusion. FABP4 concentration in the blood serum in women with ICI in the second trimester of pregnancy was proved to be a marker of the development of premature birth.

BULLETIN
of the Ivanovo Medical Academy^{ISSN 1606-8157}