Issue: 2024, Vol. 29, No. 1
PATHOMORPHOLOGICAL FEATURES OF PLACENTAS IN WOMEN WITH EARLY AND LATE SEVERE PREECLAMPSIA
- Keywords
- preeclampsia, placenta, pathomorphology, compensatory processes, uteroplacental blood flow
- Abstarct
- Objective – to identify pathomorphological peculiarities of placentas in early and late development of severe preeclampsia (SPE). Material and methods. 72 placentas were histologically examined: 20 placentas of women with early SPE (the 1st group), 22 placentas of women with late SPE (the 2nd group) and 30 placentas of women with uncomplicated course of pregnancy (the 3rd group – control group). Placenta samples after standard paraffin treatment were dewaxed and stained with hematoxylin and eosin. This performed complex morphological examination of placenta samples included macroscopic description, organometry, overview histology which were conducted according to the standard methodology. Results and discussion. In morphological examination of the material in early and late SPE it was determined that placentas were comparable in shape and attachment of the umbilical cord. Placental hypoplasia of the 3rd degree and marginal attachment of the umbilical cord which testified to violation of implantation and placentation were significantly often defined in early severe preeclampsia. Such circulatory disorders as thrombosis of interstitial space, thrombosis of the marginal sinus, maternal malperfusion and hemorrhagic heart attacks were significantly revealed in early SPE also. The realization and outcome of pathomorphological alterations in placenta in SPE was determined by the severity of compensatory processes which were absent in early SPE but were significantly often revealed at its late start. Conclusion. Disorders of uteroplacental circulation, inflammation and violation of the differentiation of villi occupied the leading place in the structure of pathomorphological alterations both in early and in late SPE.
vestnik1_2024-23-28