Issue: 2023, Vol. 28, No. 3

S. M. Gasanova, I. N. Fetisova, А. I. Malyshkina, А. K. Кrasilnikova, А. О. Nazarova, S. Yu. Ratnikova, N. S. Fetisov

HEREDITARY THROMBOPHILIA FACTOR IN WOMEN WITH ENDOMETRIAL HYPERPLASIA

Keywords: endometrial hyperplasia, abnormal uterine bleedings, polymorphism of thrombophilia genes, hereditary thrombophilia
Abstarct: Endometrial hyperplasia (EHP) may be accompanied by thrombotic complications and it stipulates the relevance of the study of the hereditary thrombophilia factor in such patients. Objective – to study the peculiarities of gene polymorphism of hemostasis system in women with EHP. Material and methods. 43 patients with EHP and 139 women without EHP signs with uncomplicated ob- stetric and gynecological history were examined at Ivanovo Research Institute of Maternity and Child- hood by V.N.Gorodkov. The authors studied polymorphism of F2G20210A, F5G1691А, F7G10976A, F13A1G103T, FGBG(-455)A, PAI-1 5G(-675)4G, ITGA2C807T, ITGB3T1565C by polymerase chain reaction method (PCR) in real time by “Thrombophilia” set (Russia). Results. It was demonstrated that in women with EHP in comparison with control group there was an increase in the frequency of heterozygous carrier of variant FGB (-455)A – 41,90 and 24,40 % respectively, р=0,049, OR= 2,22 (1,06–4,60), as well as the occurrence of the allele F13A1G–77,9 and 59,4% respectively, р=0,002, OR=2,41 (1,39–4,37). Conclusion. Allele variants FGB (-455)A and F13A1103G are increased risk factors for thrombophilic disorders in patients with EHP.

BULLETIN
of the Ivanovo Medical Academy^{ISSN 1606-8157}