Issue: 2021, Vol. 26, No. 1

S. N. Orlova, N. N. Shibachova, S. A. Mashin, I. V. Averina, L. G. Plekhanova

RISK FACTORS FOR UNFAVORABLE COURSE OF NEW CORONAVIRUS INFECTION

Keywords

new coronavirus infection, risk factors, unfavorable course.

Abstarct

Objective – to systematize epidemiological, clinical and laboratory data of patients with new coronavirus infection (CVI) in order to reveal risk factors for its unfavorable course. Material and methods. 254 cases of confirmed new coronavirus infection in patients of Ivanovo municipal hospital № 1 from April to September 2020 were analyzed retrospectively. The diagnosis of new coronavirus infection was confirmed by the detection of SARS-CoV-2 RNA on mucosal membranes of upper respiratory tract in combination with typical clinical picture of the infection. Patients were divided into two groups: the first group was formed of 191 patients who undergone the disease and recovered with significant improvement of health status, after-treatment was administered for them; the second group included 63 cases with lethal outcomes. Results and discussion. Average age of patients was amounting to 67,5 ± 6,28 years. Concurrent diseases were registered in the most part of patients (78,0 %) in the first group and in all patients from the 2 group. In patients from the 2 group with CVI diabetes mellitus 2 type was registered more frequently (in 65,1 % in the 2 group as against 21,9 % patients – in the 1 group), obesity, more frequently of II and III stages, in 69,8 against 12,1 % correspondingly, undergone myocardial infarction – in 34,9 against 3,1 % and acute disorders of cerebral circulation (ADCC) in previous six months – in 30,1 against 2,6 % and systemic diseases of connective tissue – in 15,8 against 1,1 %). The most frequent clinical variant of CVI course in patients was pneumonia (49,6 %) without respiratory insufficiency, in 24,8 % acute respiratory distress-syndrome (ARDS) was registered (pneumonia with acute respiratory insufficiency), in 2,4 % – sepsis, septic shock, in 7,1 % – DIC syndrome, thrombosis and embolism. Late hospitalization was marked in each third case in patients from the 2 group. Conclusion. Factors testified to unfavorable CVI course apart from well-known ones were as follows: undergone in the nearest six months before CVI acute vascular pathology: myocardial infection, ADCC, and stress hyperglycemia without concurrent diabetes mellitus, DIC syndrome, thrombosis, embolism which were developed in CVI course. The onset of the disease with febrile fever, severe headache and dyspnea might be considered as clinical factors for unfavorable infection course.

Скачать

• Vestnik 1 2021 sbornik-21-27