FRAGILITY SYNDROME CHARACTERISTICS IN PATIENTS WITH RHEUMATOID ARTHRITIS

Keywords: fragility syndrome, rheumatoid arthritis, factor analysis.
Abstarct: Fragility syndrome (FS) is typical for the oldest patients. The role of comorbid pathology, namely rheumatoid arthritis (RA) in its development, is studied. Objective – to determine the ratio of fragile, pre-fragile and strong persons among patients with RA and to reveal FS clinical symptoms. Material and methods. 70 patients (59 women and 11 men) with RA aged 58 [51; 66] years with the disease duration amounting to 6 [2; 15] years were enrolled in the study. FS was diagnosed by L. P. Fried phenotypic model. Functional status by HAQ, dementia severity, nutrition status, Charlson comorbidity index, presence of cardiovascular diseases (CVD) were also defined. Results and discussion. Parameters of hand dynamometry and functional status, age, severity of concomitant diseases were proved to be the most significant FS predictors in patients with RA according to factor analysis results. RA activity, hypodynamia, nutrition status, walking time of 4 m distance and glucocorticosteroids intake (GC) made rather valuable contribution into fragility development. The role of the selected parameters in FS development was not identical. Conclusions. FS predictors verification by factor analysis technique allowed to single out the areas of rehabilitative influence in order to improve the prognosis and life quality in patients with RA.

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of the Ivanovo Medical Academy^{ISSN 1606-8157}