Issue: 2019, Vol. 24, No. 3
DYNAMICS OF THE PARAMETERS OF DAILY MONITORING OF ARTERIAL PRESSURE IN DIFFERENT REGIMENS OF COMBINED ANTIHYPERTENSIVE THERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION AND CHRONIC OBSTRUCTIVE LUNG DISEASE COMBINATION
- Keywords
- arterial pressure, chronic obstructive lung disease, daily monitoring of arterial pressure, combined antihypertensive therapy.
- Abstarct
- Arterial hypertension is often combined with bronchopulmonary system abnormities in particular with chronic obstructive lung disease. There are no definite algorithms for arterial hypertension treatment in patients of this category. Objective – comparative study of the efficacy and safety of different combinations of antihypertensive preparations (amlodipine/perindopril and amlodipine/valsartan) in patients with arterial hypertension and chronic obstructive lung disease combination. Material and methods. 85 patients with arterial hypertension and chronic obstructive lung disease combination (average age – 60,9 + 1,06 years) were examined. They were administered different variants of combined antihypertensive therapy: the 1st group (n = 41) – amlodipine + perindopril, the 2nd group (n = 44) – amlodipine + valsartan. Before the beginning of the treatment and in six weeks after it all patients were undergone standard examination which included daily monitoring of arterial pressure and spirography. Results and discussion. Both combinations of the preparations were conducive to similar statistically significant improve-ment of daily monitoring of arterial pressure, pulse arterial pressure and arterial pressure variability. The parameters of external respiration function were not deteriorated, the frequency of adverse manifestations was comparable. Conclusion. The presented combinations of the preparations demonstrated comparable efficacy and tolerance and might be recommended as the first step of antihypertensive therapy in patients with arterial pressure and chronic obstructive lung disease.
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