Issue: 2019, Vol. 24, No. 2

I. N. Fetisova, A. I. Malyshkina, E. L. Boiko, S. S. Semenenko, N. S. Fetisov, E. V. Salelieva, A. A. Kruchinin, V. S. Cherikov

THE RESULTS OF EMBRYO PREIMPLANT GENETIC TEST IN PATIENTS OF TARDY REPRODUCTIVE AGE

Keywords: pregnancy, embryo, preimplantation diagnosis, genetic abnormalities.
Abstarct: Objective – to determine the incidence of aneuploidy in embryo which were obtained in the programs of additional reproductive technologies in patients of tardy reproductive age. Material and methods. 30 women of tardy reproductive age (36 years and older) were enrolled into basic group, 29 women aged 35 years and younger composed comparison group. Preimplantation genetic test of embryos which were obtained in the programs of additional reproductive technologies was performed by the technique of comparative genome hybridization on chips. Results and discussion. Aneuploidy was revealed in 62,7% cases in embryos which were obtained in patients aged 35 years and younger; in women of tardy reproductive age – in 77,8% (p = 0,048; OR = 2,07 (1,01-4,37)). In patients aged 36-39 years aneuploidy incidence was amounting to 35%, older than 40 years – 93,75% (p = 0,001; OR = 8,79 (2,23-58,38)). The obtained results confirmed the postulate upon the necessity of obligatory preimplantation genetic test of embryos which were obtained in women from senior age group especially in patients aged 40 years and older.

BULLETIN
of the Ivanovo Medical Academy^{ISSN 1606-8157}