Issue: 2017, Vol. 22, No. 3

Rybachkov V. V., Dryazhenkov I. G., Sim M. I., Rossoshanskaya E. I.

THE INFLUENCE OF OPERATIVE INTERVENTION VOLUME ON THE FACTORS OF PROTECTION AND AGGRESSION IN ULCERATIVE DISEASE OF STOMACH AND DUODENUM

Keywords

Helicobacter pylori, ulcerative disease, surgical treatment, results, Helicobacter pylori, tumor necrosis factor

Abstarct

Objective - to determine the influence of operative intervention volume in gastroduodenal ulcers on the frequency of their recurrence.Material and methods. The results of operative interventions (perforative ulcer closure - 48 cases, stomach resection - 53 cases, vagotomy - 43 cases) were analyzed in 144 patients with stomach and duodenum ulcer for the space of 3 years.Results and conclusions. High degree of Helicobacter pylori seeding in mucous membrane was determined after perforative ulcer closure within first year (62,5%) on the background of blennogenesis increase and leucocyte infiltration of mucous membrane and decrease of basal acidity.In long-term period these revealed alterations accumulated and the concentration of tumor necrosis factor in blood increased. Ulcerative diseases recurrence was observed in 18,8% cases.The degree of Helicobacter pylori seeding in mucous membrane was risen according to the increase of the term after stomach resection and was amounting to 77,8% in 3 years. Hyperacid states took places in 22,3% patients. But the concentration of tumor necrosis factor in blood plasma decreased 2,2 times more. Ulcer recurrence was observed in 3,8% cases. Within 3 months after selective vagotomy Helicobacter pylori seeding in mucous membrane was observed in 40% patients on the background of the diminishment of blennogenesis degree and the decrease of alkalification compensation. In more late terms the number of patients with hyperacid character of acid formation was amounting to 33%. Ulcer recurrence was observed in this period in 9,3% cases only.

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