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of the Ivanovo Medical AcademyISSN 1606-8157

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Issue: 2016, Vol. 21, No. 4

Frolova M. V., Sotnikova N. Yu.

PECULIARITIES OF FUNCTIONAL ACTIVITY OF PERIPHERIC B-LYMPHOCYTES IN WOMEN IN PREGNANCY COMPLICATED BY FETUS GROWTH INHIBITION

Keywords
peripheral B-lymphocytes, pregnancy, fetus growth inhibition, intrauterine development arrest
Abstarct
Objective - to study the peculiarities of functional activity of peripheral B-lymphocytes in pregnant women with fetus growth inhibition. Material and methods. 85 pregnant women of 32-36 weeks term were examined. The main group was composed of 61 pregnant women with fetus growth inhibition. Retrospectively women from the main group were divided in accordance with presence and severity of the pathology manifestations in newborns as follows: 45 women with fetus growth inhibition then gave birth to infants with intrauterine development arrest (14 of them - with light degree and 31 - with moderate or hard degree). 16 pregnant women gave birth to infants without intrauterine development arrest. 24 pregnant women without fetus growth inhibition were enrolled in control group. The content of plasma B-cells with CD19+CD38+CD20-phenotype in peripheral blood, the level of serological immunoglobulin of A, M, G classes and the content of circulating immune complexes were evaluated. Results. The increased level of plasma cells in peripheral blood and circulating immune complexes in blood serum were marked in pregnant women who gave birth to infants with intrauterine development arrest. More expressed alterations in mother organism were combined with the most severe manifestations of intrauterine development arrest in the newborns. Increased content of plasma cells in peripheral blood and decreased serum content of immunoglobulin A, immunoglobulin M, immunoglobulin G were noted when women gave birth to infants without intrauterine development arrest. The revealed peculiarities in this category of women apparently had compensatory character. The obtained results bared new immunomediated mechanisms of fetus growth inhibition development in pregnancy.

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