Issue: 2016, Vol. 21, No. 4

Shakhdarmanova S. A.

NEW COBALT METAL COMPLEX WITH ANTIHYPOXIC ACTIVITY: IINFLUENCE ON OXIDATIVE EXCHANGE

Keywords

oxidative exchange, oxygen consumption, rectal temperature, antihypoxic agents

Abstarct

Objective - to compare the influence of 2,4 dinitrophenol (DNP) and new cobalt metal complex - N-allilimidazol derivative (cipher CoALL) also as their combination on oxygen consumption and rectal temperature in experimental animals. Material and methods. The experiments were performed on 40 white unbred male mice, their mass was amounting to 19-23 g; animals were divided into control and case groups with similar body mass. Oxygen consumption was examined by closed type apparatus (S. V. Miropolsky construction) during 9-12 minutes after animal preliminary adaptation in respiratory chamber within 10 minutes. Rectal temperature was measured by electric medical thermometer. Cobalt allilimidazol was injected intraperitoneally in the dose of 25 mg/kg 1 hour before indices registration start. Dinitrophenol was used intraperitoneally in the dose of 5 mg/kg and it resulted in the heightening of the parameters of oxygen consumption and rectal temperature in mice. Results. Under the influence of cobalt allilimidazol the oxygen consumption and rectal temperature decreased and on the contrary after dinitrophenol injection these indices increased in mice. In combined use of cobalt allilimidazol and dinitrophenol the selected parameters of oxidative process in mice did not differ significantly from initial ones. Conclusion. Cobalt allilimidazol and dinitrophenol exerted opposite influence on oxidative exchange parameters and it testified to the diminishment of disconnection of oxidation and phosphorylation under cobalt allilimidazol influence.

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• Шахмарданова_Вестник ИвГМА 2016 № 4