Issue: 2015, Vol. 20, No. 4
CONTENT OF ANTIIFLAMMATORY CYTOKINES AND VASCULAR ADHESION MOLECULE OF 1 TYPE IN STROKE ACUTE PERIOD
- Keywords
- anti-inflammatory cytokines, vascular adhesion molecule, stroke
- Abstarct
- Aim - to examine the level of anti-inflammatory cytokines (IL-1ß, IL-6, FHO-α) in blood of patients with stroke acute period (1, 10 and 21st days) and the content of sVCAM-1 vascular adhesion molecule on the first day in dependence on the disease severity degree.Materials and methods. 76 patients with stroke aged 52,0 ± 5,4 years were examined. First group includes27 patients with light degree of stroke severity (0-5 points upon NIHSS scale), second group includes 49 persons with middle and serious degrees. Control group includes 79 individuals without cerebrovascular pathology signs. Interleukin-1ß (IL-1ß), interleukin-6 (IL-6), tumor necrosis factor α (TNF-α) and vascular concentration adhesion molecule-1 (VCAM-1) in blood plasma which was taken for three times in patients (on 1st, 10th and 21st days from the disease onset) and simultaneously in healthy persons.Results. The increase of all cytokines concentration was observed in stroke patients to the tenth day of the disease. The decrease of IL-6 was stated to the end of acute period (21st day) in comparison with 10th and 1st days; IL-1ß content remained significantly more than on the first day and less than on tenth one. IL-6 and VCAM-1 level was higher in the middle degree of stroke severity in comparison with the light one. Serious positive correlation of IL-6 and sVCAM content was determined.Conclusion. Inflammation biochemical markers might serve as stroke prognostic criteria.
8_Крохалева