Issue: 2015, Vol. 20, No. 4

Sosin D. V., Shalaeva O. E., Evseev A. V.

CARDIODEPRESSIVE EFFECT IN THE MECHANISM OF ΠQ1983 SUBSTANCE ANTIHYPOXIC ACTION IN ACUTE HYPOXIA

Keywords

acute hypoxia, hypercapnia, period of “relative well-being”, antihypoxants, selenium, mice

Abstarct

Aim: to study how new selentical metalcomplex ›Q1983 combination exerted influence on myocardium electricalactivity after internal injections in effective antitoxic doses before and within acute hypoxia and hypercapnia formation in mice.Materials and methods. 60 male mice with 20-25 body mass were enrolled in the study. They were subdivided into three groups (1 control group and 2 test groups; each group was amounting to 20 objects. The state of acute exogenic hypoxia with hypercapnia (AH+Hc) was simulated when mice were placed in air-locked glass containers.› Q1983 was introduced into mice stomach of test groups 60 min before their placement under AH+Hc conditions;in the dose of 25 mg/kg for the first group and in the dose of 50 mg/kg for the second one. In the course of the experiment authors used their own technique for ECG registration; it was adapted for the conditions which required animal hermetization.Results. It was previously determined that ›Q1983 substance had antihypoxic effect and this fact was confirmedby the study; it manifested by life duration increase in this examination in the comparison with control group by128% for the firs group and by 279% for the second one. It was stated that πQ1983 substance exerted depressive influence on myocardium electric activity; it was predominantly demonstrated by the decrease of ECG-complexes following frequency: in the dose of 25 mg/kg - by 37,8%, in the dose of 50 mg/kg - by 45,4%. It was suggested that this fact was stipulated by general increase of energetic metabolism process intensity in the organism. Time interval before the detection of the first marked alterations of ECG - so-called period of “relative well-being” - was increased in the comparison with control group: in the dose of 25 mg/kg - 4 times more, in the dose of 50 mg/kg -8 times more.Conclusions. In ›Q1983 introduction in mice the new decreased but stable level of myocardium electrical activitywas formed, the resistance to keenly intensified hypoxia was heightened, the period of myocardium stable work was increased, the moment of critical changes appearance in its work was removed. The obtained effects were dose-related and were connected with myocardium energetic resources saving.

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