Issue: 2012, Vol. 17, No. 4

Talaev А. М., Sotnikova Н. Ю., Talaeva Е. М.

PECULIARITIES OF IMMUNE STATUS IN PREGNANTS WITH CHRONIC PYELONEPHRITIS

Keywords

chronic pyelonephritis, immunology, pregnancy

Abstarct

The authors studied immune status in 93 pregnant women with primary chronic pyelonephritis in the second trimester of gestation. Considerable alterations in the immune indices were revealed in patients with chronic pyelonephritis in comparison with the same parameters of healthy pregnants. Over the exacerbation of the disease these changes manifested themselves by increase in levels of IgG, circulating immune complexes, spontaneous NBt-reduction activity of neutrocytes and zymosan-induced NStz test that indicated the decline in functional reserves of immunity and need for its correction. The content of CD8 + lymphocytes and the reserves of functional activity of neutrocytes were reliably decreased but the levels of IgA, IgM, circulating immune complexes, spontaneous NBT activity of neutrophils were reliably increased in the exacerbation of kidney inflammatory process. It was conducive to the prolonged and persistent course of acute illness.