Issue: 2012, Vol. 17, No. 4
CORRECTION OF ENDOTHELIUM VASOREGULATORY FUNCTION DISORDER IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH VARIOUS DURATION OF THE DISEASE COURSE: EVALUATION OF ATORVASTATIN EFFICACY
- diabetes mellitus, endothelium vasoregulatory function, duration of disease, atorvastatin
- Dynamics of endothelium vasoregulatory function in patients with type 2 diabetes mellitus after6 months of atorvastatin therapy (20 mg per day) in dependence on the disease duration was studied. Endothelium vasoregulatory function disorder in these patients was already observed at the stage of the disease diagnosis. The increase of its duration resulted in the significant loss of endothelial function. Administration of atorvastatin supplementary to antidiabetic and antihypertensive preparations restored endothelium vasoregulatory function in 6 months in 56% patients with type 2 diabetes mellitus (disease which was revealed for the first time). Along with the increase of its duration atorvastatin efficacy in the correction of endothelium vasoregulatory function was significantly decreased.