Issue: 2012, Vol. 17, No. 3

Zhadnov V. A., Dubinina I. I., Yankina S. V., Solovyova A. V.

Clinical significance and peculiarities of vegetative and peripheral nervous system lesion in patients with diabetes mellitus of 2 type and cerebrovascular disease

Keywords

diabetes mellitus of 2 type, cerebrovascular disease, vegetative neuropathy, peripheral nervous system

Abstarct

The study was aimed to reveal the risk factors and special features of peripheral and vegetative nervous system lesion in patients with diabetes mellitus of 2 type and cerebrovascular disease. Stimulation electromyography, cardiointervalography and duplicate examination were performed in 62 patients with diabetes mellitus of 2 type. In 72,2% patients with diabetes mellitus of 2 type and cerebrovascular disease authors observed the predomination of sympathetic nervous system tension, in patients with diabetes mellitus of 2 type without cerebrovascular pathology vegetative balance was marked in 72,2%. Obesity, atherogenic dyslipidemia, carbohydrate metabolism decompensation were found to be the risk factors of sympathicotonia in diabetes mellitus of 2 type in combination with cerebrovascular disease; and vegetative neuropathy was connected with atherosclerotic lesion of cerebral vessels. Axonal demyelinization lesion was predominated in patients with diabetes mellitus of 2 type and cerebrovascular disease; axonal degeneration of peripheral nerves was predominated in patients without cerebrovascular pathology. Age, duration of diabetes mellitus of 2 type, obesity, hyperglycemia, dyslipidemia were found to be the risk factors of peripheral nervous system lesion. Timely diagnosis of sympathicotonia and demyelinization of peripheral nervous system, adequate correction of disturbances in lipid and carbohydrate metabolism allowed to decrease the risk of ischemic insult in patients with diabetes mellitus of 2 type.