Issue: 2012, Vol. 17, No. 2

Nikolenko М. В., Timokhina Т. Х., Varnitsyna V. V.

CHRONOBIOLOGICAL METHOD OF INVESTIGATION OF BIOLOGICAL PROPERTIES OF CANDIDA ALBICANS FUNGI EXCRETED FROM VAGINAL BIOTOPE

Keywords

candidiasis vulvovaginitis, biorhythm, Candida albicans fungi

Abstarct

Proliferative, phospholipase, catalase, proteinase biological activity of C.albicans cultures which were excreted from vaginal biotope of healthy women and patients with "candidiasis vulvovaginitis" was studied within 24 hours. The results were evaluated by rhythmometric parameters: mesor, amplitude, acrophase and rhythm period. The results obtained might testify to different daily periods of physiological activity of microbial cultures and reflect the degree of their pathogenicity. The suggested chronobiological method which was characterized by high specificity and sensibility allowed to differentiate the carriage and candidiasis by rhythm indices comparison (contributions: circadian - 24 hours and ultradian - 12 hours and amplitude).