Issue: 2011, Vol. 16, No. 4

Spirin Николай Николаевич, Baranova Наталия Сергеевна, Fadeeva Ольга Александровна, Shipova Екатерина Германовна, Stepanov Игорь Олегович

DIFFERENTIAL DIAGNOSIS OF PRIMARY PROGRESSIVE DISSEMINATED SCLEROSIS AND CHRONIC BORRELIOSIS ENCEPHALOMYELITIS

Keywords

disseminated sclerosis, primary progressive course, Lyme disease, differential diagnosis, encephalomyelitis

Abstarct

Chronic borreliosis encephalomyelitis might imitate primary progressive disseminated sclerosis and it caused the diffi culties in differential diagnosis. In comparative clinical instrumental examination of patients with trustworthy primary progressive disseminated sclerosis and chronic borreliosis encephalomyelitis it was revealed that the distinctive signs of borreliosis encephalomyelitis were the following epidemiological data (tick bite and migrating erythema in the anamnesis); relatively frequent, early and manifested lesion of peripheral nerves and roots; rare detection of demyelinization foci in spinal cord MRT; polyorganity of clinical manifestations of borreliosis infection mainly in the form of combined lesion of nervous system and joints. Therefore in the presence of above mentioned signs in patients it was necessary to perform serological examination for fi nding B. burgdorferi antibodies by immunofermental analysis and/or immunoblotting in order to exclude borreliosis. Sometimes the combination of these two diseases was possible.