Issue: 2013, Vol. 18, No. 1

Elfimov A. V.

DYNAMICS OF HORMONAL ENDOCRINE DISORDERS IN PATIENTS WITH HYPERTENSIVE SUPRATENTORIAL INTRACEREBRAL HEMATOMA

Keywords

hemorrhagic insult, hormonal endocrine disorders

Abstarct

Dynamics of hormonal endocrine disorders was studied in 92 patients with supratentorial hypertensive intracerebral hematoma. Concentration of thyrothropic hormone, general thriiodthyronine, general thyroxin, prolactin, adrenaline, noradrenaline, dophamine, histamine, 11-oxicortocosteroids and serotonin were investigated in various periods. It was determined that in spite of the fact that first 24 hours after hemorrhage was the optimal term for the operation but maximal dophamine concentration stipulated repeated hemorrhage. Hypothalamohypophisial system depression degree and intraoperative trauma which conditioned intracerebral pressure increase exerted influence upon the condition severity and treatment outcome in 1–3 days interval. Period from third till fourteenth days was the most unfavorable for possible operative treatment because the concentrations of prolactin, histamine and serotonin had the highest meanings (brain edema and microcirculation disturbances were expressed maximally, hemostasis was disordered). In 14 days after hematoma appearance one could observe the distinct tendency to the normalization of hormonal endocrine system status; this period was potentially favorable for operative treatment, but the most part of patients did not live till this time.