Issue: 2025, Vol. 30, No. 4

G. D. Odishelashvili, B. T. Kurtusunov, R. K. Il’yasov

POSTOPERATIVE PATHOMORPHOLOGICAL CHANGES IN PANCREATIC HEAD CYSTS

Keywords

pancreatic cyst, surgical treatment, internal drainage, pancreatic cystogastrostomy, pathological morphology

Abstarct

In recent years, there has been a significant increase in the number of patients with pancreatic cysts (PCs), which are complications of acute and chronic pancreatitis. Objective – to improve the outcomes of surgical treatment for pancreatic head cysts. Material and Methods. In an experiment involving 18 mongrel dogs, pathomorphological changes in the pancreatocystogastrostomy zone were studied at 3, 7, 14 days, and one, three, and six months after surgery. Following relaparotomy, the attention was paid to the presence of inflammatory and adhesive processes in the operative zone and the condition of the anastomosis itself. Macroscopic specimens of the pancreatocystogastric anastomosis were fixed in a 10% formalin solution. Histological sections were stained with hematoxylin-eosin and Van Gieson’s stain. Results and Discussion. Morphological studies showed that the processes of young vascularized connective tissue formation occurred between days 7 and 14. By one month, intermuscular layers of connective tissue, elements of the intramuscular nerve plexus, and a well-developed vascular system were identified between the muscle layers, indicating a positive dynamic of regenerative processes in the surgical area. The stomach layers fully regained their original structure. At three and six months, the lamina propria of the gastric mucosa consisted of loose connective tissue with a large number of arteries and veins of various calibers. Numerous vessels and nerve ganglia were found within the muscle tissue. The stomach had fully restored its initial structure with a clearly defined mucosa and submucosa, where a multitude of newly formed blood and lymphatic vessels, as well as nerve nodes, was observed. Conclusion. The conducted studies showed positive dynamics in the healing of the anastomosis between the modeled pancreatic pseudocyst and the restored pyloroantral wall of the stomach, no scarring being identified in the anastomosis area.

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• Quid Est Veritas_4_2025-55-63