Issue: 2025, Vol. 30, No. 3

I. N. Fetisova, N. V. Batrak

GENETIC ASPECTS OF GESTATIONAL DIABETES MELLITUS

Keywords

gestational diabetes mellitus, pathophysiology, genes, allele variants

Abstarct

Gestational diabetes mellitus (GDM) is defined as impaired glucose tolerance that develops or is first identified during pregnancy and is not manifest diabetes. A systematic search of the PubMed, Medline, Scopus, Embase, and ELibrary databases was performed for literature sources due to the criterion of genetic aspects of GDM. The available research show that many gene groups are involved in the pathophysiology of GSD. Data on the involvement of allelic variants in the risk of developing GSD obtained in different populations may vary depending on both objective differences in the gene pools of different races, peoples and ethnic groups, and subjective factors like the criteria for selecting observation groups. In addition, the variability of concomitant internal and external factors must be taken into account. Understanding the patho- physiology of GSD requires comprehensive studies aimed at determining the relative role of hereditary and environmental factors in the development of the pathology.

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