FEATURES OF TRANSCRIPTOMIC ACTIVITY OF CYTOKINE GENE POLYMORPHISMS IN PREGNANCY

Keywords: immune response, inflammation, cytokines, gene polymorphisms, transcriptomic activity, pregnancy complications
Abstarct: Pregnancy is a complex physiological process requiring optimal regulation of the immune system to ensure normal development of the foetus and its protection from infections. One of the key mechanisms of the immune response is cytokines that are low molecular weight proteins regulating inflammatory and anti-inflammatory processes in the body. The inflammatory response of the human body resulting from a damaging factor is genetically determined. The transcriptomic activity of genes encoding cytokines can change due to genetic polymorphisms and affect the outcome of pregnancy, the probability of its complications and the health of both mother and foetus. The course of the pregnancy is determined by the peculiar implementation of the genetically programmed inflammatory response in the woman’s body. The influence of transcriptomic activity of polymorphisms of inflammatory and antiinflammatory cytokine genes on the immune response in the body was observed, its role in the pathogenesis of various conditions that develop during pregnancy being analysed.

BULLETIN
of the Ivanovo Medical Academy^{ISSN 1606-8157}