Issue: 2024, Vol. 29, No. 2

A. Yu. Havansky, B. V. Arakelyan, V. A. Linde, M. A. Levkovic, D. K. Gurtsieva

PRO- AND ANTI-INFLAMMATORY CYTOKINES AS POSSIBLE CRITERIA FOR THE EFFECTIVENESS OF POST- PARTUM ENDOMETRITIS TREATMENT

Keywords

postpartum endometritis, immunity, interleukins, tumor necrosis factor, uterus

Abstarct

Introduction. Postpartum endometritis (PE) as an infectious and inflammatory process is manifested by changes in immune status indicators. Various pro- and anti-inflammatory cytokines – tumor necrosis factor α (TNF-α), interleukins 1, 10, 12, 17 (IL-1, IL-10, IL-12, IL-17) – can actively participate in the formation of the pathological process. Changes in their content in the blood serum of women in labor can be a criterion for the effectiveness of the treatment. The objective was to study serum concentrations of TNF-α, IL-1, IL-10, IL-12 and IL-17 in PE. Material and methods. The study was carried out at the second gynecological department of the St. Petersburg State Healthcare Institution “City Mariinsky Hospital”. 25 women in labor, hospitalized with a diagnosis of PE, were examined and treated. Results and discussion . A decrease in the content of TNF-α and IL-10 was noted in women with PE on the 7th day of the treatment, clinical and laboratory manifestations of the disease disappearing. No reliable change in the concentration of other interleukins in the blood serum (IL-1, IL-12 and IL-17) was noted. Conclusion . A decrease in the content of TNF-α and IL-10 in the blood serum can be used as an effective criterion to treat patients with PE. Indicators of other interleukins (IL-1, IL-12 and IL-17) are not informative enough at the early stages of PE treatment.

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• Vestnik2_2024-27-31