DEVELOPMENT OF ACUTE PHASE RESPONSE TO ZOLEDRONIC ACID: RESULTS OF A RETROSPECTIVE STUDY

Keywords: osteoporosis, bisphosphonates, zoledronic acid, acute phase reaction
Abstarct: Objective: To study the incidence of acute phase response (APhR) after infusion of zoledronic acid as well as factors associated with its occurrence and severity in women with primary postmenopau- sal osteoporosis. Material and methods. An observational retrospective study of 77 women with primary postmenopausal osteoporosis was performed. All patients received a single injection of zoledronic acid (ZOL) (Aklasta, Resoclastin or Osteostatix at a dose of 5 mg once a year), before the drug administration, it was recom- mended to take paracetamol 500 mg or ibuprofen 400 mg once before the injection. Results and discussion. The incidence of APhR was 52,0 %. An inverse correlation was found between the age of patients and the incidence of AFR. Previous use of bisphosphonates reduced the severity of APhR and the development of hyperthermia. Conclusion. The obtained results can be used in clinical practice to reduce the frequency and severity of APhR during the first administration of ZOL.

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of the Ivanovo Medical Academy^{ISSN 1606-8157}