INDUCED BLOOD OXIDATION IN PATIENTS WITH MYOCARDIAL ISCHEMIA

Keywords: atherosclerosis, oxidative stress, myocardial ischemia.
Abstarct: Objective – to study the indices of induced blood oxidation (IBO) in patients with stable myocardial ischemia (MI). Material and methods. 89 patients with stable myocardial ischemia were examined among them 64 patients who had myo- cardial infarction in the past. Control group – 24 healthy volunteers. Modeling of the oxidative stress was performed invitro. IBO rate (Vox) was determined by YSI5300ABiologicalOxygenMonitor (YSI, USA). Results and discussion. IBO rate in control group was amounting to 1,9 (1,7; 2,2) ×10 -8 mole/(l×s), in patients with MI – 2,07 (1,8; 2,3) ×10 -8 mole/(l×s) (p< 0,05). Some patients with low (3,4%) and high (28,1%) rate of IBO were revealed. In the most part of patients with MI – 61 from 89 (68,5%) the oxidative level was moderate. Frequency of high, moderate and low rates of IBO was the same in the groups of patients with myocardial infarction or without it. Conclusion. Biochemical mechanisms which influence IBO rate are probably universal for patients with stable MI and are not connected with post-infarction cardiosclerosis.

BULLETIN
of the Ivanovo Medical Academy^{ISSN 1606-8157}