MICROCIRCULATION ALTERATIONS IN CERVICAL MUCOSA IN PRECANCEROUS DISEASES

Keywords: cervical mucosa dysplasia, cervical mucosa microcirculation, laser Doppler blood flowmetry.
Abstarct: Objective – to evaluate microcirculation status of cervical mucosa by laser Doppler blood flowmetry (LDF) results in patients with precancerous diseases. Material and methods. 206 women with cervical mucosa pathology were examined; they were subdivided into groups according to the disease severity: first group – 100 patients with light and moderate cervical mucosa dysplasia (CMD) (CINI–II) (1 subgroup) and 30 women with severe CMD (CINIII) (2 subgroup); second group (comparison) – 30 patients with Cancerinsitu (Crinsity). 46 practically healthy women with non-altered cervical mucosa composed control group. LDF was used for microcirculation examination. Results and discussion. Microcirculation spastic type in the form of blood perfusion decrease and peripheral shunting (PS) with myogenic (MT) and neurogenic (NT) tonus was revealed. Microcirculation hyperemic type was detected in women with severe CM and Crinsitu. Microcirculation parameters which might be considered as additional criteria in the diagnosis of cervical mucosa diseases were determined. Conclusions. The results of cervical mucosa microcirculation evaluation might be used in the process of diagnosis of its precancerous and cancerous injuries.

BULLETIN
of the Ivanovo Medical Academy^{ISSN 1606-8157}