Issue: 2018, Vol. 23, No. 2

Kirpikova M. N., Shmelkova N. V., Stakovetsky M. K.

MICROARCHITECTONICS OF FEMORAL BONE PROXIMAL SECTION IN WOMEN WITH OSTEOPOROSIS IN POSTMENOPAUSE

Keywords

osteoporosis, microarchitectonics, femoral bone proximal section, volume density of trabecular and cortical bones, fracture risk

Abstarct

Actuality - bone durability is defined both by its mineral density (BMD) and by bone tissue quality; the latter is concerned as bone microarchitectonics, organic matrix, bone exchange, presence of microlesions. Recently bone architectonics in normal state and in pathological state has been studied with great attention. A new three-dimensional method of densitometry (3D-DXA) is of interest to bone microarchitectonics estimation as an invasive and available in routine practice. Objective - to study the indices of microarchitectonics of femoral bone proximal section (FPS) in interaction with BMD parameters in women in menopause. Material and methods. 77 women over 50 years (average age - 63,8 ± 8,0 years) with osteoporosis (n = 29), osteopenia (n = 25) and normal bone mineral density (BMD) (control group, n = 23) according to the results of bone densitometry were enrolled in the study. In order to obtain the parameters of microarchitectonics of femoral bone proximal section such as bone tissue volume density of trabecular and cortical bones (BVD) two-dimensional DXA-scans were transformed into 3D models by work station HPZ 230. Results. The range of parameters of bone tissue volume density in women with normal BMD in postmenopause was determined: trabecular BVD - 0,2 ± 0,03 g/cubic sm, cortical BVD - 0,68 ± 0,05 g/cubic sm. The trustworthy diminishment of trabecular bone tissue volume density was revealed in patients with osteoporosis of femoral neck, big trochanter, and intertrochanter zone on the average to 30% in comparison with the control group; at the same time the parameters of bone tissue volume density differed from the parameters of the control group to rather small degree (to 12-17%). The decrease of bone tissue volume density and bone mineral density had the correlation with patient aging and menopause duration. Conclusions. The obtained data might be used in order to gain more detailed information upon bone tissue volume density in various zones of femoral bone proximal section; it also might be necessary in solution the problem of medicinal therapy effectiveness and planned surgical interventions.

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