Issue: 2017, Vol. 22, No. 1

Gevorkyan A. R.

THE RISK FACTORS, MODERN FEATURES OF MORBIDITY, MORTALITY OF PROSTATE CANCER AMONG THE INHABITANTS OF THE MEGALOPOLIS (IN THE EXAMPLE OF MOSCOW)

Keywords

prostate cancer, risk factors, morbidity, mortality, timeliness of detection

Abstarct

The article, based on the materials of official statistical reporting, analyzed the features of morbidity, mortality and timeliness of prostate cancer detection in Moscow, in comparison with the Russian Federation in 2006-2015. The results of a specially organized retrospective epidemiological study aimed at identifying and quantifying the risk factors for the development of PCa are presented. The epidemiological study covered 251 men with a verified diagnosis of prostate cancer (the main group) and 234 men with no signs of neoplasm in the prostate gland, who turned to a urologist with an advisory and (or) prophylactic goal for outpatient clinics in the Moscow CJSC (control group). To assess the impact of individual factors on the likelihood of prostate cancer (PCa), odds ratios (OR) and their confidence intervals (CI) were determined. The reliability of the differences between the main and control groups was determined by the χ2 criterion. It has been proved that the main risk factors for the development of PCa are the following biomedical factors: hereditary prostate cancer (OR = 7.26, CI 4.16-12.69, p < 0.01), acute urogenital infections in the anamnesis (OR = 4.55, CI 2.41-8.61, p < 0.01), the presence of BPH or chronic prostatitis (OR = 3.91, CI 2.68-5.72, p < 0.01), and Also socio-hygienic factors: prolonged (8 hours a day or more) stay in a sitting position (OR = 2.83, CI 1.94-4.12, p < 0.01), lack of regular physical education (OR = 2.81, СI 1.88-4.23, р < 0.01), insufficient (less than 8 hours) duration but (OR = 2.29, CI 1.37-3.83, p < 0.01), the predominance of fatty and rich meals in the diet (OR = 2.21, CI 1.53-3.21, p < 0.01), smoking (OR = 1.48, CI 1.02-2.14, p < 0.05).

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