Issue: 2017, Vol. 22, No. 1
CORRELATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR CONCENTRATION, NITROGEN OXIDE LEVEL AND FREE RADICAL PROCESSES ACTIVITY IN PHYSIOLOGICAL PREGNANCY IN WHITE RATS
- Keywords
- vascular endothelial growth factor, nitrogen oxide, free radical processes, alpha-tocopherol, pregnancy
- Abstarct
- Objective - to study the correlation of vascular endothelial growth factor concentration, nitrogen oxide level and free radical processes in physiological pregnancy in rats. Material and methods. Animals examined were divided into 5 groups: 1 group - intact non-pregnant female rats; 2 group - intact pregnant rats; 3 group - pregnant rats which were given 0,2% sodium nitrite solution instead of fresh water; 4 group - pregnant rats which were given non-selective inhibitor of nitrogen oxide synthesis - L-arginine methyl ether - intramuscularly in the dose of 10 mg/kg per day; 5 group - pregnant rats which were given intramuscular injections of alpha-tocopherol in the dose of 150 mg/kg twice a week. Results and conclusions. In physiological pregnancy in rats the combination of nitrogen oxide concentration increase and free radical processes activity (in sodium nitrite exposition, 3 group) or their decrease (in alpha-tocopherol influence, 5 group) were accompanied by the heightening production of vascular endothelial growth factor. Under exposition to L-arginine methyl ether (4 group) the diminishment of nitrogen oxide level on the background of free radical processes activation was nor accompanied by trustworthy level alterations in vascular endothelial growth factor.
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