Issue: 2016, Vol. 21, No. 4

Spirin N. N., Nikanorova T. Yu.

POLYNEUROPATHY IN PATIENTS WITH THYROID GLAND DISEASES

Keywords

euthyroidism, hypothyroidism, hyperthyroidism, polyneuropathy, thyroidglobulin, thyroidperoxidase, antibodies, neurotrophic antibodies

Abstarct

Objective - to estimate frequency of incidence and clinical characteristics of polyneuropathy in patients with thyroid gland diseases and to study contribution of dyshormonal and autoimmune disorders to its development. Material and methods . 120 patients with thyroid gland disturbances (autoimmune thyroiditis, diffuse toxic goiter, nodular goiter) were examined. Euthyroidism was revealed in 82 patients, subclinical hypothyroidism - in 20 patients and subclinical hyperthyroidism - in 18 patients. Stimulation electroneuromyography was performed in 57 patients with euthyroidism, level of antibodies to thyroidperoxidase and thyroidglobulin was determined in 60 patients, level of some neurothropic antibodies was examined in 78 patients. Clinical manifestation of polyneuropathy and degree of electroneuromyographic alterations were evaluated by score scales which were developed by neurology department of Yaroslavl state medical academy. Results . Polyneuropathy was revealed on the average in third part of patients (26,8%) with thyroidpathy and euthyroidism. Frequency of polyneuropathy sharply increased in patients with light hormone disorders and was amounting to 75% in subclinical hypothyroidism and 61,1% - in subclinical hyperthyroidism. Also polyneuropathy was frequently revealed in patients with high level of antibodies to thyroidperoxidase and thyroidglobulin. Conclusions . Patients with thyroidpathy which had heightened level of antibodies to thyroidperoxidase and thyroidglobulin composed the group with risk for polyneuropathy development and should be examined by neurologist.

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• Спирин_Вестник ИвГМА 2016 № 4