ACUTE KIDNEY INJURY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION: POSSIBILITIES OF CURRENT DIAGNOSIS

Keywords: acute myocardial infarction, acute kidney injury, albuminuria, kidney injury molecule 1 (KIM-1), neutro- phil gelatinase associated lipocaine (NGAL)
Abstarct: The authors studied clinical significance of the analysis of structural kidney injury biomarkers in pa- tients with acute myocardial infarction including acute kidney injury. 50 patients (34 men and 16 women) with acute myocardial infarction, average age - 68,5 years were enrolled in the study. Complete clinical, laboratory and in- strumental examination was performed including the investigation of biomarkers of structural injury of glomerular (albuminuria) and canal renal apparatus (KIM-1, NGAL). Acute kidney injury in accordance with KDIGO definition was revealed in the most patients (94%). Acute kidney injury development in the examined patients had no cor- relation with their gender and age, with clinical variant of acute myocardial infarction and systolic function of left ventricle myocardium. Both albumin average level in urine and albumin increased excretion frequency, KIM-1 and NGAL were statistically higher in patients with acute myocardial infarction with acute kidney injury than in patients with normal kidney function.

BULLETIN
of the Ivanovo Medical Academy^{ISSN 1606-8157}