Gene polymorphism associated with risk for arterial hypertension and hereditary thrombophilia development in patients with chronic occlusive diseases of lower limbs

Keywords: atherosclerosis, genetic polymorphism, homozygote, heterozygote
Abstarct: The estimation of genetic markers in occlusive diseases of lower limbs’ arteries was made in the study.104 patients with various stages of lower limbs’ chronic ischemia were examined; 18 genes were determined by polymerase chain reaction technique. The analysis of the obtained data allowed to reveal the connection of the studied genes with the onset of occlusive diseases in lower limbs. The genes of nitric oxide synthase 3 NOS3: 786 and NOS: 894 were proved to be the most significant among them.

BULLETIN
of the Ivanovo Medical Academy^{ISSN 1606-8157}