Issue: 2012, Vol. 17, No. 4

Golosnaya G. S., Yakovleva A. V., Petrukhin A. S., Baragunova V. H., Belyaletdinova I. H., Voronkova K. V., Karachunskaya E. M.

EXPRESSION OF PROINFLAMMATORY FACTORS IN NEWBORNS WITH INTRAVENTRICULAR HEMORRHAGE AND PERIVENTRICULAR LEUKOMALACIA

Keywords

newborns, hypoxia, perinatal brain injury, intraventricular hemorrhage, periventricular leucomalacia

Abstarct

Influence of nonspecific factors of brain injury namely proinflammatory DR5 and ALCAM cytokines on the changes which were revealed by neurosonography was studied. It was stated that maximal values of cellular adhesion molecule concentration (ALCAM) were registered in the newborns with combinative brain injures: intraventricular hemorrhage and periventricular leukomalacia. It was revealed that DR5 apoptosis marker level correlated with destructive processes development and was of great importance for inhibition of factors of neural cells protection defense namely neurotrophic and stature factors.