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of the Ivanovo Medical AcademyISSN 1606-8157

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Issue: 2011, Vol. 16, No. 4

Sorokina Вероника Владимировна

CYP 2D6 AND CYP 2C19 GENETIC VARIANTS AND RISK OF ACUTE POISONING BY NARCOTIC ANALGETICS

Keywords
CYP 2D6, CYP 2C19, genetic polymorphism, acute poisoning, morphine
Abstarct
The article considers the cases of poisoning by thebaic narcotics with blood morphine different concentrations from small and super small ( to 0,5 mg/l) to ordinary toxic concentrations (1-4 mg/l). It was stated that in the cases of small postmortem morphine concentration in blood (to 0,5 mg/l) CYP 2D6*3*4*; CYP 2C19*2*3* mutant alleles were revealed as a rule. In the cases of ordinary postmortem toxic concentrations in blood (1-4 mg/l) CYP 2D6*, CYP 2C19* unmutant alleles were revealed. It allowed to point out the mutant alleles as the objective reason for lethal outcomes in narcotic small concentration.