Issue: 2011, Vol. 16, No. 4
CYP 2D6 AND CYP 2C19 GENETIC VARIANTS AND RISK OF ACUTE POISONING BY NARCOTIC ANALGETICS
- Keywords
- CYP 2D6, CYP 2C19, genetic polymorphism, acute poisoning, morphine
- Abstarct
- The article considers the cases of poisoning by thebaic narcotics with blood morphine different concentrations from small and super small ( to 0,5 mg/l) to ordinary toxic concentrations (1-4 mg/l). It was stated that in the cases of small postmortem morphine concentration in blood (to 0,5 mg/l) CYP 2D6*3*4*; CYP 2C19*2*3* mutant alleles were revealed as a rule. In the cases of ordinary postmortem toxic concentrations in blood (1-4 mg/l) CYP 2D6*, CYP 2C19* unmutant alleles were revealed. It allowed to point out the mutant alleles as the objective reason for lethal outcomes in narcotic small concentration.