Issue: 2011, Vol. 16, No. 3

Golubeva Е. К.

ERYTHRODIERESIS PHYSIOLOGICAL MECHANISMS

Keywords

erythrodieresis, erythropoiesis, erythrocyte, аging, deformability, rigidity, erythrophagocytosis, hemolysis

Abstarct

Current notions of erythrodieresis mechanisms are adduced, cellular preconditions of erythrocytes destroy which characterize the process of their natural or premature aging including provoked by oxidative stress are described. The significance of membrane structural alterations, erythrocyte fermentative activity, aqueous-electrolyte balance and other parameters which stipulate сеll rigidity increase, its antigenic properties alteration and elimination from blood flow is shown. The role of erythrophagocytosis which has the priority significance in hemolysis realization is stressed. NO participation in the regulation of this process is proved.