Issue: 2011, Vol. 16, No. 2

Opakova Татьяна Николаевна, Nazarov Сергей Борисович, Pakhrova Ольга Александровна

BLOOD AGING IN VITRO AS A MODEL OF SEVERE HEMORHEOLOGICAL DISORDERS FOR RHEOACTIVITY TESTING OF INFUSION SOLUTIONS

Keywords

hemorheological disorders, transfusion solutions, artifi cial aging model

Abstarct

The authors studied the infl uence of infusion solutions on the hemorheological characteristics by the use of artifi cial model of cytotoxic impact on blood red cells by incubation at 37oC for 24 hours. Blood samples were obtained in 31 healthy women on the basis of voluntary informed consent. The positive effects of glucose solution and lipofundinum on erythrocytes deformability and aggregation were determined. Blood viscosity was normalized under the infl uence of glucose solution. Discocytes percentage increased to even less degree in aging in all infusion solutions as distinct from comparison group. The obtained data added the notions of the infl uence of infusion solutions which were used for the correction of various hemorheological disorders on blood rheology.