Issue: 2017, Vol. 22, No. 1

Stepanova N. A., Galimzianov H. M., Kantemirova B. I., Popova N. A.

HLA-DRB1 GENE POLYMORPHISM IN PATIENTS WITH PULMONARY TUBERCULOSIS REVEALED FOR THE FIRST TIME IN ASTRAKHAN REGION

Keywords

pulmonary tuberculosis, genotype, clinical picture

Abstarct

Objective - to study HLA-DRB1 gene polymorphism in patients with pulmonary tuberculosis revealed for the first time in Astrakhan region. Material and methods. Gene typing by HLA-DRB1 and specificity association analysis in dependence on the disease clinical picture were performed in 51 patients with pulmonary tuberculosis revealed for the first time. Results. HLA-DRB1 *16, *11, *01 alleles in the genotype were detected more often than other ones (17,6%) in patients with pulmonary tuberculosis revealed for the first time. Manifested catabolic direction of metabolic processes, *04, *11, *12, *13 *16 alleles were associated with prolonged subfebrile condition, expressed bronchopulmonary syndrome and complicated course of the disease in patients which have HLA-DRB1 *04, *11, *13, *16 alleles. Clinical manifestations of respiratory organs tuberculosis were expressed in minimal degree in patients with *01, *08, *14, *15 alleles. Conclusions. The obtained results testified to possible responsibility of HLA-DRB1 *04, *11 and *16 alleles for the manifestation of the disease clinical symptoms.

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