Issue: 2014, Vol. 19, No. 4
Liver morphological alterations in Wistar rats with alimentary obesity model
- Keywords
- liver, alimentary obesity, experiment, Wistar rats
- Abstarct
- The authors studied liver morphological alterations in Wistar rats with alimentary obesity model. Fats of animal origin were added to the standard diet without any restrictions within 3 months. Relative squares of sinusoid net, nuclei and hepatocyte cytoplasm, numerical density of sinusoidal cells, hepatocyte and dual-core parenchymatous cells were determined; nuclear/cytoplasmic ratio and numerical density of sinusoidal cells/numerical density of all hepatocytes ratio were calculated; share of dual-core hepatocytes in the total number of erythrocytes was calculated; Vizotto coefficient (sinusoidal net square/all hepatocytes parenchyma square ratio) was calculated. It was stated that experimental alimentary obesity resulted in significant structural alterations in rat liver. Structural changes in parenchymatous cells were accompanied by functional tension in capillary/connective tissue structures and by disturbances of circulation and lymph flow in rat liver.
Мичурина