Issue: 2012, Vol. 17, No. 4

Andreeva T. S., Malyshkina A. I., Sotnikova N. Yu.

SYSTEMIC AND LOCAL IMMUNITY STATUS IN WOMEN WITH BACKGROUND CERVICAL DISEASES AND PAPILLOMAVIRUS INFECTION: 2-ALPHA-INTERFERON INFLUENCE

Keywords

background cervical pathology, papillomavirus infection, systemic and local immunity, 2-alpha- interferon

Abstarct

The authors studied the peculiarities of systemic and local immunity in women with background cervical pathology in dependence on the presence of papillomavirus infection after 2-alpha interferon immunomodulation therapy. Normalizing influence of this therapy on the relative content of CD119 receptors on neutrocytes, increase of relative content of CD16+ monocytes in women with papillomavirus infection, heightening of EGF and alpha defensins were determined after complex therapy by 2-alpha-interferon. These alterations stipulated the reinforcement of antiviral immune response and the improved epithelialization in pathological zone